Claire Redfield is one of the main characters in the Resident Evil series appearing in Resident Evil 2, Resident Evil Code: Veronica, Resident Evil: The Darkside Chronicles and the CGI film Resident Evil: Degeneration. The younger sister of fellow main character Chris Redfield, Claire is an avid motorcyclist, and a member of Terra Save. She was present in Raccoon City during the t-Virus outbreak, and was a fundamental figure in the Anti-Umbrella movement.
Claire is the younger sister of Chris Redfield, who was one of the main characters from the original game. She comes to Raccoon City in search of her brother, but finds something much worse. After she is saved from nearly being eaten alive by a virus carrier, Claire and Leon S. Kennedy hatch a plan to get out Raccoon City as soon as they can. After they are separated, Claire explores the deserted police station, eventually running into the corrupt Chief Irons and Sherry Birkin, the daughter of two important Umbrella researchers, William Birkin & Annette Birkin. Claire meets Annette on at least one occasion, during which she accuses Claire of being a spy. As Sherry and Claire look for a way out of the city, they are stalked by the mutated Birkin. While inside of the sewers, Sherry and Claire are separated, during which time Sherry is found by Birkin and infected with the G-Virus. Upon reuniting, Claire attempts to find a cure for Sherry within Umbrella's underground labs. While in the laboratory, Claire runs into Annete one more time, before William arrives and fatally wounds his former wife. Before dying, Annette gives Claire the instructions for creating the G-Virus antidote, DEVIL. Soon after creating the antidote, Claire attempts to make her escape, having Leon take Sherry to an escape train before the lab self destructs. Her escape, however, is thwarted once again by Birkin, forcing her to fight the monster and incapacitate it. Claire then rushes to the train, joining Leon, and successfully administering the vaccine to Sherry. Unfortunately, Birkin, now a gigantic, amorphous blob, attacks the train, thus triggering another self-destruct sequence. Claire, Leon, and Sherry escape moments before the train explodes, destroying Birkin once and for all. Not long after their escape, Leon urges her to leave them and go search for her brother.
Three months after her escape from Raccoon City, Claire headed over to Europe to finally find her lost brother Chris. Having no luck, she even got imprisoned at a small island far off in the sea. Due to her strong will to survive and to find her brother she is able to again find her way through the island once it has been attacked by an unknown enemy. Another viral outbreak happened on the island. During her attempt to escape, Claire runs into Steve Burnside, another prisoner on the island, and the two eventually join forces. During this time, Claire also encounters Alfred Ashford, who insists that Claire had led enemy forces to the base, and who then releases multiple B.O.W's to stop her. Claire also has a run-in with her brother's old rival, Albert Wesker, who decides to leave her as "bait" to get Chris to arrive at the island. As all of this happens, Claire soon finds out about Alexia Ashford, and has a supposed run-in with "her", only to be saved by Steve, who then shoots "Alexia", revealing that it is none other than Alfred. As the two find a cargo plane to escape the island, Alfred then sends out the T-078 Tyrant to deal with the two survivors, and also has the plane's auto-pilot redirected, sending the two survivors directly to Antarctica. Upon arriving at the base, Claire and Steve find that the entire facility has been infected by the t-Virus. They manage to locate an Australian research base nearby. After having one last showdown with Alfred, she and Steve use a snowmobile to escape the Australian base, but are forced to deal with Nosferatu before leaving. Things seem fine as the two head for the base, until a dying Alfred manages to awaken the REAL Alexia from stasis, who then holds them captive.
When Chris finally arrives at the Antarctic facility, he manages to rescue Claire, but is separated from her once again by Alexia. To make matters worse, Claire soon finds Steve, who has been infected with the t-Veronica virus, thus causing him to mutate. Claire is forced to escape from the monster, only to be nearly killed by a giant tentacle. Steve suddenly comes to his senses, and frees Claire, only to be mortally wounded in the process. As he reverts to his human form, he confesses his love to Claire, and dies by her side.
Distraught, Claire manages to give Chris instructions for initializing a self-destruct sequence, before eventually reuniting with him. After Chris kills the mutated form of Alexia once and for all, he attempts to escape with Claire, only to be interrupted by Wesker. Once their confrontation is over, Chris and Claire evacuate in a jet, determined to bring Umbrella down, once and for all.
Claire had joined a non-government organization called Terra Save, which campaigned against Bio-terrorism. She arrived in Harvardville Airport to meet a friend who too was part of Terra Save, but was caught up in a Bio-terrorism event herself after an outbreak of the t-virus occurred within the airport.
Stuck in the airport, Claire tried to find a way to escape with the others in her party, which included Rani Chawla, Ron Davis, and an airport employee. After calling 911 and waiting for help, a sudden scream followed by gunfire give Claire the knowledge of other survivors. Maneuvering into the hallways to find them, wielding only an umbrella, she eventually came into contact with Leon S. Kennedy and his party. After escaping the airport, Claire headed to WilPharma with Frederick Downing. Once there she learned that the G-Virus was being held there. As she called Leon, a time bomb set off, causing a shard of glass to embed itself within her leg severely affecting her mobility. While escaping WilPharma, Claire tried to help Leon and Angela Miller from Curtis Miller, who had mutated due to an injection of the G-virus, behind the scenes. Once Curtis was disposed of the three survivors cornered Frederick, who had been involved with the attacks in India and Harvardville, and arrested him. With the threat of any further outbreaks temporarily subdued Claire and Leon opt to meet again under more normal circumstances as Leon rushes off to his next mission.